Negotiated prices for the first ten selected drugs took effect on January 1, 2026, with maximum fair prices set between 38 and 79 percent below 2023 list prices. Eliquis, for example, moved from a list price near $592 a month to roughly $231. The Centers for Medicare and Medicaid Services projected about $6 billion in program savings in the first year plus roughly $1.5 billion in reduced out-of-pocket costs. Actual savings depend on plan design, since what a patient pays still varies by tier and copay structure.